my account
Login
  Loading... Please wait...

Product Details

Antibiotic A-23187 | Ca2+ ionophore

Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative phosphorylation.2 In addition, antibiotic A-23187 inhibits ATPase activity.3

References/Citations
1) Reed and Lardy (1972) A23187: a divalent cation ionophore; J. Biol. Chem, 247 6970
2) Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria; Arch. Biochem. Biophys, 156 578
3) Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase; J. Biol. Chem., 261 16584

swipe
Focus Biomolecules cell signaling tech supplier, chemical structure of Antibiotic A-23187 | Ca2+ ionophore | CAS 52665-69-7

Catalog#  10-2284

$90.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
52665-69-7
Catalog Number:
10-2284
Activity:
Ca2+ ionophore
Alternate Names:
Calcimycin
Molecular Weight:
523.62
Molecular Formula:
C29H37N3O6
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 4 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Antibiotic A-23187 | Ca2+ ionophore to your wish list.