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Apomorphine HCl | Dopamine agonist

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s disease.4,5

References/Citations

1) Merck Index 14:746
2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791
3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612
4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279
5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsoism. Related. Disord., 33 Suppl. 1:S13

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Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7

Catalog#  10-1338-0100

$40.00
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CAS:
41372-20-7
Catalog Number:
10-1338
Activity:
Dopamine agonist
Chemical Name:
(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinolone-10,11-diol hydrochloride
Alternate Names:
R-(-)-6aβ-aporphine-10,11-diol hydrochloride Hemihydrate
Molecular Weight:
312.78
Molecular Formula:
C17H17NO2• HCl H2O
Solubility:
Soluble in Water (up to 20 mg/ml)
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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