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Product Details

BC-11-38 | PDE-11 inhibitor

A potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 mM).1  IC50s for PDE1-10 are greater than 100 mM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2

References/Citations
1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155
2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223

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Focus Biomolecules cell signaling reagent supplier, chemical structure of BC-11-38 | PDE-11 inhibitor | CAS 686770-80-9

Catalog#  10-1408

$90.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
686770-80-9
Catalog Number:
10-1408
Activity:
PDE-11 inhibitor
Chemical Name:
6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one
Molecular Weight:
304.44
Molecular Formula:
C15H16N2OS2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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