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Benztropine mesylate | Induces remyelination of neurons

Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3 Inhibits hepatitis C virus infection.4

References/Citations

1) Zhang et al. (2001), Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues; J. Med. Chem., 44 3937
2) Schmitt et al. (2008), Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties; J. Neurochem., 107 928
3) Deshmukh et al. (2013), A regenerative approach to the treatment of multiple sclerosis; Nature, 502 327
4) Mingorance et al. (2014), Selective inhibition of hepatitis C virus infection by hydroxyzine and benztropine: Agents Chemother., 58 3451

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Catalog#  10-2324-0001

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CAS:
132-17-2
Catalog Number:
10-2324
Activity:
Induces remyelination of neurons
Chemical Name:
3-(Endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate
Molecular Weight:
403.53
Molecular Formula:
C21H25NO &bul; CH4SO3
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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