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Bromotetramisole, L(-) oxalate | Alkaline phosphatase inhibitor

Bromotetramisole oxalate (62284-79-1) is a potent alkaline phosphatase inhibitor.1 Strongly activates cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels by inhibiting a membrane associated protein phosphatase.2 Bromotetramisole oxalate inhibits terminal cell division-associated differentiation in murine erythroleukemia cells.3

References/Citations

1) Kovach et al. (1992), Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase; J. Natl. Cancer Inst., 84 515
2) Luo et al. (2000), Role of protein phosphatases in the activation of CTFR (ABCC7) by genistein and bromotetramisole; Am. J. Physiol. Cell Physiol., 279 C108
3) Scher et al. (1998), The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis; Int. J. Oncol., 12 987

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Catalog#  10-1527-0005

$48.00
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CAS:
62284-79-1
Catalog Number:
10-1527
Activity:
Alkaline phosphatase inhibitor
Chemical Name:
(-)-(S)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate
Alternate Names:
L-p-Bromotetramisole oxalate; (-)-p-Bromolevamisole
Molecular Weight:
373.22
Molecular Formula:
C11H11BrN2S &bul; C2H2O4
Solubility:
Soluble in Water (up to 10 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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