my account
  Loading... Please wait...

Product Details

C16 | PKR inhibitor

C16 (608512-97-6) inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM).1 Inhibits ER stress-induced neuronal damage.2 Reduces brain PKR activation in vivo.3  Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model.4 Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures.5 Cell permeable.

1) Jammi et al. (2003), Small molecule inhibitors of the RNA-dependent protein kinase; Biochem. Biophys. Res. Commun., 308 50
2) Shimazawa et al. (2007), Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage; Ophthalmol. Vis. Sci., 48 3729
3) Ingrand et al. (2007), The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation; FEBS Lett. 581 4473
4) Tronel et al. (2014), The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component; Neurochem. Int. 64 73
5) Couturier et al. (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures; Neuroinflammation, 8 72

Focus Biomolecules cell signaling reagent supplier, chemical structure of C16 | PKR inhibitor | CAS 608512-97-6

Catalog#  10-1329

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
PKR inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 15 mg/ml, with warming).
Physical Properties:
Orange solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the C16 | PKR inhibitor to your wish list.