Calyculin A | Protein phosphatase inhibitor

Calyculin A Chemical structure

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Calyculin A (101932-71-2) is a  potent cell permeable inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A), IC50=0.3-1 nM.1 Has no effect on PP2B, PP2C as well as acid or alkaline phosphatase at 1 mM.2  A non-phorbol tumor promoter.3 Stimulates the phosphorylation of various cellular proteins such as vimentin4  and NFkB5 and also induces membrane translocation of protein kinase C6.

References/Citations:

  1. Ishihara et al. (1989), Calyculin A and okadaic acid: inhibitors of protein phosphatase activity; Biochem. Biophys. Res. Commun.159 871
  2. Swingle et al. (2009), Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol. 365 23
  3. Fujiki et al. (1991), Mechanisms of action of okadaic acid class tumor promoters on mouse skin; Environ. Health Perspect. 93 211
  4. Tzivion et al. (2000), Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo; J. Biol. Chem. 275 29772
  5. Tanaka et al. (2007) Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells; Int. J. Oncol. 31 389
  6. Gopalakrishna et al. (1992), Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C; Biochem. Biophys. Res. Commun. 189 95
101932-71-2, Calyculin, Calyculin A, Calyculin A supplier, PP1 inhibitor, PP2 inhibitor, Protein phosphatase inhibitor

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Calyculin A (101932-71-2) is a  potent cell permeable inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A), IC50=0.3-1 nM.1 Has no effect on PP2B, PP2C as well as acid or alkaline phosphatase at 1 mM.2  A non-phorbol tumor promoter.3 Stimulates the phosphorylation of various cellular proteins such as vimentin4  and NFkB5 and also induces membrane translocation of protein kinase C6.

References/Citations:

  1. Ishihara et al. (1989), Calyculin A and okadaic acid: inhibitors of protein phosphatase activity; Biochem. Biophys. Res. Commun.159 871
  2. Swingle et al. (2009), Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse; Methods Mol. Biol. 365 23
  3. Fujiki et al. (1991), Mechanisms of action of okadaic acid class tumor promoters on mouse skin; Environ. Health Perspect. 93 211
  4. Tzivion et al. (2000), Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo; J. Biol. Chem. 275 29772
  5. Tanaka et al. (2007) Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells; Int. J. Oncol. 31 389
  6. Gopalakrishna et al. (1992), Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C; Biochem. Biophys. Res. Commun. 189 95