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Captopril | Angiotensin-converting enzyme inhibitor

Captopril (62571-86-2) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM).1 Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4> formation and Ki = 60 nM for L-lysine-p-nitroanilide).2 Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.

References/Citations

1) Cushman et al. (1999), Design of angiotensin converting enzyme inhibitors; Nat.Med., 5 1110
2) Orning et al. (1991), Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril; J.Biol.Chem., 266 16507

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Focus Biomolecules reagent supplier, chemical structure Captopril | Angiotensin-converting enzyme inhibitor | CAS 62571-86-2

Catalog#  10-2253

$30.00
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CAS:
62571-86-2
Catalog Number:
10-2253
Activity:
Angiotensin-converting enzyme inhibitor
Chemical Name:
(2S)-1-(3-Mercapto-2-methyl-propionyl)-L-proline
Molecular Weight:
217.28
Molecular Formula:
C9H15NO3S
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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