CBA | TRPM4 blocker

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5 mg$45.00
25 mg$155.00
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CBA (351424-20-9) is a selective blocker of TRPM4 channels (IC50 = 1.5 mM) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors.1 Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.2 A highly useful tool for exploring the functions of TRM4 in a variety of cell types.3,4

References/Citations:

  1. Ozhathil et al. (2018), Identification of potent and selective small molecule inhibitors of the cation channel TRPM4; Br. J. Pharmacol. 175 2504
  2. Bianchi et al. (2018), The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration; Mol. Brain 11 41
  3. Borgstrom et al. (2021), Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions; J. Mol. Biol. 433 166665
  4. Diszhazi et al. (2021), TRPM4 links calcium signaling to membrane potential in pancreatic acinar cells; J. Biol. Chem. 297 101015
351424-20-9, CBA supplier, TRPM4 antagonist, TRPM4 blocker, TRPM4-IN-5, TRPM4-IN-5 supplier
Alternate Name:
TRPM4-IN-5

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

CBA (351424-20-9) is a selective blocker of TRPM4 channels (IC50 = 1.5 mM) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors.1 Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.2 A highly useful tool for exploring the functions of TRM4 in a variety of cell types.3,4

References/Citations:

  1. Ozhathil et al. (2018), Identification of potent and selective small molecule inhibitors of the cation channel TRPM4; Br. J. Pharmacol. 175 2504
  2. Bianchi et al. (2018), The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration; Mol. Brain 11 41
  3. Borgstrom et al. (2021), Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions; J. Mol. Biol. 433 166665
  4. Diszhazi et al. (2021), TRPM4 links calcium signaling to membrane potential in pancreatic acinar cells; J. Biol. Chem. 297 101015