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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A77 1726 | DHODH inhibitor | CAS 108605-62-5
    A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to...

  • AGI-5198 | R132 mutant isocitrate dehydrogenase inhibitor
    AGI-5198 (135526-35-0) is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1  It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2  This mutation results in...

  • Focus Biomolecules supplier, chemical structure of FCCP | Inhibits mitochondrial oxidative phosphorylation | CAS 370-86-5
    FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HQNO | NADH oxidase inhibitor | CAS 341-88-8
    HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent...

  • Leflunomide | Immunosuppressant
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Lonidamine | Inhibits Cancer Cell Metabolism
    Lonidamine (50264-69-2) was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as well as aerobic and anaerobic glycolysis in tumor cells leading to apoptosis.2...

  • N-Oleoylphenylalanine | Structure | Supplier
    N-Oleoylphenylalanine is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-Oleoylphenylalanine binds directly to mitochondria and functions as an endogenous uncoupler...

  • Oligomycin Complex | Mitochondrial ATPase inhibitor
    Oligomycin (1404-19-9) inhibits mitochondrial F1F0 ATP synthase.1 A useful tool for decreasing cellular ATP levels.2 Induces autophagy.3 Stimulates lysosome acidification.4 Oligomycin protects against ischemic kidney in male...

  • TTFA | Mitochondrial Complex II inhibitor
    TTFA (326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp...

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