Mitochondrial
Showing 1–12 of 14 results
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Cellular Metabolism
A77 1726 | DHODH inhibitor
A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH)...$45.00 – $150.00 Select options -
Cancer
AGI-5198 | R132 mutant isocitrate dehydrogenase inhibitor
AGI-5198 (135526-35-0) is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1 It is selective for the R132H-IDH1 mutant...$40.00 – $95.00 Select options -
New Products
Brequinar sodium | Dihydroorotate dehydrogenase inhibitor, antiviral
Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 ...$70.00 – $275.00 Select options -
New Products
Canagliflozin | SGLT2 inhibitor
Canagliflozin (842133-18-0) is a potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM, selective over SGLT1, IC5...$44.00 – $148.00 Select options -
Cancer
CPI-613 | KGDH and PDH inhibitor
CPI-613 (95809-78-2) is a lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows s...$50.00 – $200.00 Select options -
Apoptosis
FCCP | Inhibits mitochondrial oxidative phosphorylation
FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell...$58.00 – $228.00 Select options -
Cellular Metabolism
HQNO | NADH oxidase inhibitor
HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial ...$85.00 – $340.00 Select options -
Cellular Metabolism
iGP-1 | Mitochondrial GPDH inhibitor
iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selec...$50.00 – $180.00 Select options -
Approved Drugs
Leflunomide | Immunosuppressant
Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug).1 Displays immunomodulatory activity inhibi...$40.00 – $160.00 Select options -
Apoptosis
Lonidamine | Inhibits Cancer Cell Metabolism
Lonidamine (50264-69-2) was originally investigated as an antispermatogenic agent.1 Lonidamine has been shown to decrease oxygen consumption as wel...$45.00 – $175.00 Select options -
AMPK
Metformin HCl | Anti-diabetic agent
Metformin HCl (1115-70-4) is a clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepati...$30.00 – $120.00 Select options -
Bioactive Lipids
N-Oleoylphenylalanine | Endogenous Uncoupler of Mitochondrial Respiration
N-Oleoylphenylalanine (136560-78-6) is an endogenous lipoamino acid produced via the action of a secreted enzyme PM20D1 produced by adipocytes. N-O...$50.00 – $200.00 Select options
