CELLULAR METABOLISM

Daily function of cells involves many biochemical pathways that continuously monitor and balance energy homeostasis. Disruption of cellular metabolism can lead to diseases that affect most systems in the body. A hallmark of cancer, for example, is a restructuring of normal cellular metabolism to meet the energetic and stress demands inherent in rapid cell growth. Diseases that involve inborn errors of metabolism (IEM’s) include phenylketonuria, Niemann-Pick disease, and glycogen storage diseases.

Complex Carbohydrates

  • Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
    CAS:
    75172-81-5
    Catalog Number:
    10-2632
  • Intelliscreen™ Cancer Cell Metabolism Library
    Catalog Number:
    10-7101
    Description:
    171 modulators of various aspects of cancer cell metabolism.
    Solubility:
    DMSO or Water
    Supplied As:
    Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $4 600.00
  • Tunicamycin | ER stress inducer
    CAS:
    11089-65-9
    Catalog Number:
    10-2111
    Activity:
    ER stress inducer
    Molecular Weight:
    840.0 (Avg)
    Molecular Formula:
    C38H62N4O16 (tun. B)
    Solubility:
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
    Physical Properties:
    White solid
    Purity:
    99% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Kifunensine | Mannosidase inhibitor
    CAS:
    109944-15-2
    Catalog Number:
    10-2860
    Activity:
    Mannosidase inhibitor
    Chemical Name:
    (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
    Alternate Names:
    FR-900494
    Molecular Weight:
    232.19
    Molecular Formula:
    C8H12N2O6
    Solubility:
    Soluble in DMSO (up to 35 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • Conduritol B epoxide | Glycosidase inhibitor
    CAS:
    6090-95-5
    Catalog Number:
    10-1172
    Activity:
    β-Glycosidase inhibitor
    Alternate Names:
    CBE
    Chemical Name:
    D,L-1,2-Anhydro-myo-inositol
    Molecular Weight:
    162.14
    Molecular Formula:
    C6H10O5
    Solubility:
    Soluble in Water (up to 25 mg/ml) or in DMSO
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Compound is hygroscopic, protect from moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Complex Carbohydrates Products

Glucose

View All Glucose Products

Glutamine

  • Intelliscreen™ Cancer Cell Metabolism Library
    Catalog Number:
    10-7101
    Description:
    171 modulators of various aspects of cancer cell metabolism.
    Solubility:
    DMSO or Water
    Supplied As:
    Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $4 600.00
  • Gilteritinib | FLT3 Inhibitor
    CAS:
    1254053-43-4
    Catalog Number:
    10-4170
    Activity:
    FLT3 inhibitor
    Chemical Names:
    6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
    Molecular Weight:
    552.72
    Molecular Formula:
    C29H44N8O3
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Off-white to pale pink solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • GAC Inhibitor 968 | Glutaminase C inhibitor
    CAS:
    311795-38-7
    Catalog Number:
    10-1538
    Activity:
    Glutaminase C inhibitor
    Chemical Names:

    5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]-phenanthridin-4(1H)-one

    Molecular Weight:
    475.42
    Molecular Formula:
    C27H27BrN2O
    Solubility:
    Soluble in DMSO (up to 11 mg/ml) or in Ethanol (up to 1 mg/ml with warming)
    Physical Properties:
    Off-white solid
    Purity:
    98%  TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • BPTES | Glutaminase GLS1 inhibitor
    CAS:
    314045-39-1
    Catalog Number:
    10-5414
    Activity:
    Glutaminase GLS1 inhibitor
    Chemical Name:
    N,N’-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
    Molecular Weight:
    524.68
    Molecular Formula:
    C24H24N6O2S3
    Solubility:
    Soluble in DMSO (10 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    98% by TLC NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
    Shipping Code:
    RT
  • R162 | Glutamate dehydrogenase 1 inhibitor
    CAS:
    64302-87-0
    Catalog Number:
    10-4603
    Activity:
    Glutamate Dehydrogenase 1 inhibitor
    Chemical Name:
    1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
    Alternate Names:
    Purpurin analog
    Molecular Weight:
    264.28
    Molecular Formula:
    C17H12O3
    Solubility:
    Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
    Physical Properties:
    Orange solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
View All Glutamine Products

Glutathione

  • Ethacrynic acid | Glutathione transferase inhibitor
    CAS:
    58-54-8
    Catalog Number:
    10-2826
  • Intelliscreen™ Cancer Cell Metabolism Library
    Catalog Number:
    10-7101
    Description:
    171 modulators of various aspects of cancer cell metabolism.
    Solubility:
    DMSO or Water
    Supplied As:
    Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $4 600.00
  • DT-109 | Induces glutathione biosynthesis
    CAS:
    14857-82-0
    Catalog Number:
    10-5732
    Activity:
    Induces glutathione biosynthesis
    Chemical Names:
    Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
    Molecular Weight:
    245.28
    Molecular Formula:
    C10H19N3O4
    Solubility:
    Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • RSL3 | GPX4 inhibitor/Ferroptosis inducer
    CAS:
    1219810-16-8
    Catalog Number:
    10-3417
    Activity:
    GPX4 inhibitor/Ferroptosis inducer
    Chemical Names:
    (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
    Alternate Name:
    1S,3R-RSL3
    Molecular Weight:
    440.88
    Molecular Formula:
    C23H21ClN2O5
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • 2-AAPA | Glutathione/thioredoxin reductase inhibitor
    CAS:
    1133387-90-2
    Catalog Number:
    10-3238
    Activity:
    Glutathione/thioredoxin reductase inhibitor
    Chemical Names:
    R,R′-2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid, hydrate
    Molecular Weight:
    518.65
    Molecular Formula:
    C18H22N4O6S4
    Solubility:
    Soluble in DMSO (50 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    95% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
    Shipping Code:
    RT
View All Glutathione Products

Kinases

View All Kinases Products

Lipid Metabolism

View All Lipid Metabolism Products

Mitochondrial

  • LW6 | Malate dehydrogenase inhibitor
    CAS:
    934593-90-5
    Catalog Number:
    10-4083
  • Vorasidenib | Isocitrate dehydrogenase 1/2 inhibitor
    CAS:
    1644545-52-7
    Catalog Number:
    10-4659
  • BML-260 | JSP-1 phosphatase inhibitor
    CAS:
    101439-76-3
    Catalog Number:
    10-5153
    Activity:
    JSP-1 phosphatase inhibitor
    Chemical Names:
    (Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
    Molecular Weight:
    341.40
    Molecular Formula:
    C17H11NO3S2
    Solubility:
    Soluble in DMSO (45 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • PF-4708671 dihydrochloride | S6K1 inhibitor
    CAS:
    125517-76-0 (free base)
    Catalog Number:
    10-4856
    Activity:
    S6K1 inhibitor
    Chemical Names:
    2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzimidazole dihydrochloride
    Molecular Weight:
    463.33
    Molecular Formula:
    C19H21F3N6·2HCl
    Solubility:
    Soluble in DMSO (at least 35 mg/ml); Water (at least 50 mg/ml)
    Physical Properties:
    White solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 1 month. Hygroscopic solid – protect from moisture.
    Shipping Code:
    RT
  • Ascochlorin | Mitochondrial cytochrome bc1 complex inhibitor
    CAS:
    26166-39-2
    Catalog Number:
    10-5296
View All Mitochondrial Products

NAD

View All NAD Products

Nucleotide

View All Nucleotide Products

Other Cellular Metabolism

View All Other Cellular Metabolism Products

Polyamine

  • Intelliscreen™ Cancer Cell Metabolism Library
    Catalog Number:
    10-7101
    Description:
    171 modulators of various aspects of cancer cell metabolism.
    Solubility:
    DMSO or Water
    Supplied As:
    Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $4 600.00
  • Mitoguazone 2HCl | Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
    CAS:
    7059-23-6
    Catalog Number:
    10-4552
    Activity:
    Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
    Alternate Names:
    MGBG
    Chemical Name:
    Methylglyoxal bis(guanylhydrazone) dihydrochloride
    Molecular Weight:
    257.13
    Molecular Formula:
    C5H12N8 2HCl
    Solubility:
    Soluble in Water (greater than 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Confirms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
  • POB | Ornithine decarboxylase inhibitor
    CAS:
    946135-39-3
    Catalog Number:
    10-4553
    Activity:
    Ornithine decarboxylase inhibitor
    Chemical Name:
    N-(4′-Pyridoxyl)-L-Ornithine(BOC)-Ome
    Molecular Weight:
    397.47
    Molecular Formula:
    C19H31N3O6
    Solubility:
    Soluble in DMSO (up to 25 mg/ml), in Water (up to 2 mg/ml) or in Ethanol (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Confirms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in distilled water are not stable and must be made fresh and used within one working day.
    Shipping Code:
    RT
  • Difluoromethylornithine HCl | Inhibits polyamine biosynthesis
    CAS:
    96020-91-6
    Catalog Number:
    10-2274
    Activity:
    Inhibits polyamine biosynthesis
    Alternate Names:
    DFMO; Eflornithine
    Chemical Name:
    DL-α-Difluoromethylornithine Hydrochloride Monohydrate
    Molecular Weight:
    236.65
    Molecular Formula:
    C6H12F2N2O2 HCl H2O
    Solubility:
    Soluble in Water (up to 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Polyamine Products

Sphingolipids

View All Sphingolipids Products

Trans-Sulfuration

  • Intelliscreen™ Cancer Cell Metabolism Library
    Catalog Number:
    10-7101
    Description:
    171 modulators of various aspects of cancer cell metabolism.
    Solubility:
    DMSO or Water
    Supplied As:
    Compounds are supplied in either DMSO or water as dictated by solubility. Three plates supplied as DMSO solutions and one plate as water solutions.
    Storage Temperature:
    -80°C
    Stability:
    Stable for up to 1 year when stored as supplied @ -80°C
    Price:
    $4 600.00
  • PF-9366 | Methionine adenosyltransferase 2A inhibitor
    CAS:
    72882-78-1
    Catalog Number:
    10-4635
    Activity:
    Methionine adenosyltransferase 2A inhibitor
    Chemical Name:
    2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine
    Molecular Weight:
    350.85
    Molecular Formula:
    C20H19ClN4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml).
    Physical Properties:
    Beige solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
  • Propargylglycine | H2S synthase inhibitor
    CAS:
    64165-64-6
    Catalog Number:
    10-1366
    Activity:
    H2S synthase inhibitor
    Chemical Name:
    2-Amino-4-pentynoic acid
    Molecular Weight:
    113.12
    Molecular Formula:
    C5H7NO2
    Solubility:
    Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Trans-Sulfuration Products