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17-AAG | HSP90 inhibitor

17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.

References/Citations:

1) Schulte et al. (1998), The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin; Cancer Chemother. Pharmacol. 42 273
2) Kamal et al. (2003), A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors; Nature, (b>425 407
3) Kaur et al. (2004), Therapeutic and diagnostic implications of Hsp90 activation; Clinical Cancer Res. 10 4813

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

1mg, 5mg

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CAS:
75747-14-7
Catalog Number:
10-1097
Activity:
HSP90 inhibitor
Chemical Name:
17-(Allylamino)-17-desmethoxygeldanamycin
Alternate Name:
Tanespimycin
Molecular Weight:
585.7
Molecular Formula:
C31H43N3O8
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Purple or dark red solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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17-AAG | HSP90 inhibitor

$32.00 – $80.00

CAS:
75747-14-7
Catalog Number:
10-1097
Activity:
HSP90 inhibitor
Chemical Name:
17-(Allylamino)-17-desmethoxygeldanamycin
Alternate Name:
Tanespimycin
Molecular Weight:
585.7
Molecular Formula:
C31H43N3O8
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Purple or dark red solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 1mg
  • 5mg
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

SKU: 10-1097 Categories: , , , , , , , Tags: , , , , ,
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