Conduritol B epoxide | Glycosidase inhibitor

Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.^1,2 May be used for generation of the “Gaucher mouse”³ and the in vitro model of the Gaucher cell⁴.

References/Citations

1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;  Biochem. Biophys. Res. Commun., 152 155
2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;  Methods Enzymol., 72 673
3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29
4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;  Biochim. Biophys. Acta, 877 121