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D(+)-Cycloserine | NMDA, glycine site partial agonist

CAS:
68-41-7
Catalog Number:
10-2279
Activity:
NMDA, glycine site partial agonist
Chemical Name:
(R)-4-Amino-3-isoxazolidone
Molecular Weight:
102.09
Molecular Formula:
C3H6N2O2
Solubility:
Soluble in Water (up to 100 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices.4 Second-line drug for the treatment of tuberculosis.  Enhances activity-dependent plasticity in human adults.5  

References/Citations:

1) Watson et al. (1990), D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes; Brain Res., 510 158
2) Baran et al. (1994), The glycine/NMDA receptor partial agonist D-cycloserine blocks kainite-induced seizures in rats. Comparison with MK-801 and diazepam; Brain Res., 652 195
3) Löscher et al. (1994), Anticonvulsant effects of the glycine/NMDA receptor ligands D-cycloserine and D-serine but not R(+)-HA-966 in amygdala-kindled rats; Br. J. Pharmacol., 112 97
4) Rouaud and Billard (2003), D-cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices; Br. J. Pharmacol., 140 1051
5) Forsyth et al. (2015), Augmenting NMDA receptor signaling boosts experience-dependent neuroplasticity in the adult human brain; Proc. Natl. Acad. Sci. USA, 112 15331

D(+)-Cycloserine | NMDA, glycine site partial agonist is also available in the Cellular Metabolism Library.
CAS:
68-41-7
Catalog Number:
10-2279
Activity:
NMDA, glycine site partial agonist
Chemical Name:
(R)-4-Amino-3-isoxazolidone
Molecular Weight:
102.09
Molecular Formula:
C3H6N2O2
Solubility:
Soluble in Water (up to 100 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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