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Dansylcadaverine | Autophagic vacuole dye

Dansylcadaverine (10121-91-2) preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids making it a very useful probe for monitoring autophagy.1,2 Inhibits EGF internalization.3 Dansylcadaverine competes with certain trans-aminases and can be used with antibody/affinity procedures to isolate resulting conjugates.4 Abs: 335 nm, Em: 510 nm

References/Citations

1) Munafo and Colombo (2001), A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci., 114 3619
2) Jiang et al. (2012), Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol., 188 1361
3) Haigler et al. (1980), Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239
4) Murthy et al. (1994), Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem., 269 22907

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Catalog#  10-2847-0100

$30.00
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CAS:
10121-91-2
Catalog Number:
10-2847
Activity:
Autophagic vacuole dye
Chemical Name:
N-(5-Amino­pentyl)-5-dimethylaminonaphthalene-1-sulfonamide
Alternate Names:
Monodansyl cadaverine; MDC
Molecular Weight:
335.46
Molecular Formula:
C17H25N3O2S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming) or in Methanol (up to 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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