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Product Details

Deoxynojirimycin | Glucosidase inhibitor

Deoxynojirimycin (19130-96-2) inhibits α-glucosidase I and II1,2. Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step3. May be used to produce an affinity ligand for purifying glucosidase 14. Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line5.

References/Citations
1) Fuhrmann et al. (1985), Inhibitors of oligosaccharide processing; Biochim. Biophys, Acta, 825 95
2) Hughs and Rudge (1994), Deoxynojirimycin: synthesis and biological activity; Nat. Prod. Rep., 11 135
3) Papandreou et al. (2002), The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step; Mol. Pharmacol., 61 186
4) Hettkamp et al. (1984), Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides; Eur. J. Biochem., 142 85
5) Suh et al. (1992), Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides; J. Biol. Chem., 267 21671

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Focus Biomolecules supplier, chemical structure of Deoxynojirimycin | Glucosidase inhibitor | CAS 19130-96-2

Catalog#  10-2409

$50.00
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CAS:
19130-96-2
Catalog Number:
10-2409
Activity:
Glucosidase inhibitor
Chemical Name:
(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol
Molecular Weight:
163.17
Molecular Formula:
C6H13NO4
Solubility:
Soluble in Water up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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