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Diltiazem | Calcium channel blocker

Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels1,2.Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells3. Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons4. Clinically useful antihypertensive agent5. Cell permeable.

References/Citations

1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387

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Diltiazem HCl | 33286-22-5 | Structure | Supplier

Catalog#  10-1139-0001

$30.00
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CAS:
33286-22-5
Catalog Number:
10-1139
Activity:
Calcium channel blocker
Chemical Name:
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one hydrochloride
Molecular Weight:
450.98
Molecular Formula:
C22H26N2O4S • HCl
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Water (up to 50 mg/ml)
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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