DT-109 | Induces glutathione biosynthesis

CAS:
14857-82-0
Catalog Number:
10-5732
Activity:
Induces glutathione biosynthesis
Chemical Names:
Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
Molecular Weight:
245.28
Molecular Formula:
C10H19N3O4
Solubility:
Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
100 mg$35.00
500 mg$85.00

DT-109 (14857-82-0) is glycine-containing peptide which has been demonstrated to ameliorate nonalcoholic fatty liver disease (NAFLD). It improved body composition, and lowered circulating glucose, lipids, transaminases, proinflammatory cytokines and steatohepatitis in mice with established NASH.1 It dose-dependently attenuates NASH and fibrosis in mice as well as in nonhuman primates.2 It induced glutathione biosynthesis in mononuclear cells and demonstrated atheroprotective activity.3

References/Citations:

  1. Rom et al. (2020), Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome; Sci. Transl. Med., 12 eaaz2841
  2. Qu et al. (2023), DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates; Cell Metab., 35 742
  3. Rom et al. (2022), Induction of glutathione biosynthesis by glycine-based treatment mitigates atheroscleosis; Redox. Biol., 52 102313
CAS:
14857-82-0
Catalog Number:
10-5732
Activity:
Induces glutathione biosynthesis
Chemical Names:
Glycyl-glycyl-L-leucine; Gly-Gly-Leu-OH
Molecular Weight:
245.28
Molecular Formula:
C10H19N3O4
Solubility:
Soluble in DMSO (25 mg/ml with warming); Water (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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