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Product Details

E-64 | Cysteine protease inhibitor

E-64 (66701-25-5) is a cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2 Inhibits calpain-dependent apoptosis pathway in T cells3 but promotes heat-induced apoptosis in FM3A cells. Typical working concentration is 0.5-10 µg/ml.4

References/Citations

1) Wang and Yuen (1994), Calpain inhibition: an overview of its therapeutic potential; Trends Pharmacol. Sci., 15 412
2) Barrett et al. (1982), L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H, and L; Biochem. J., 201 189
3) Sarin et al. (1994), Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors; J. Immunol., 153 862
4) Zhu et al. (1996), Promotion of heat-induced apoptosis in FM3A cells by protease inhibitors; Biochem. Biophys. Res. Commun., 225 924

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E-64 |  66701-25-5 | Structure | Supplier

Catalog#  10-1345-0005

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
66701-25-5
Catalog Number:
10-1345
Activity:
Cysteine protease inhibitor
Chemical Name:
(2S.3S)-trans-Epoxy succinyl-L-leucylamido-(4-guanidino) butane
Molecular Weight:
357.41
Molecular Formula:
C15H27N5O5
Solubility:
Soluble in a 1:1 mixture of Ethanol and Water (up to 20 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in 1:1 ethanol/water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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