EPAC 5376753 | EPAC inhibitor

EPAC 5376753 is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2

References/Citations

1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148
2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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Catalog Number:
10-1564
Activity:
EPAC inhibitor
Chemical Name:
5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight:
367.21
Molecular Formula:
C15H8Cl2N2O3S
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Orange-red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

EPAC 5376753 | EPAC inhibitor

$60.00$240.00

Catalog Number:
10-1564
Activity:
EPAC inhibitor
Chemical Name:
5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight:
367.21
Molecular Formula:
C15H8Cl2N2O3S
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Orange-red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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