Ferrioxamine E | Siderophore

CAS:
 20008-20-2
Catalog Number:
 10-5156

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Ferrioxamine E (20008-20-2) is a hydroxamate siderophore. Siderophores like Ferrioxamine E make iron easier to access and absorb by cells. Their ability to chelate iron makes them useful in research on iron overload disorders such as hemochromatosis and sickle cell disease.1 Ferrioxamine E is used to enhance growth of certain bacterial species including Salmonella, Enterobacter saka-zakii and Yersinia enterocolitica.2 It does not improve growth of Escherichia coli, Shigella, Proteus, Providencia and Morganella species.3 Because siderophores are produced by bacteria as virulence factors, they are useful tools in infectious disease research.4

References/Citations:

  1. Nagoba and Vedpathak (2011), Medical Applications of Siderophores; Eur. J. Gen. Med. 8 229
  2. Pless and Reissbrodt (1995), Improvement of Salmonella detection on motility enrichment media by ferrioxamine E-supplementation of pre-enrichment culture; Int. J. Food Microbiol. 27 147
  3. Reissbrodt et al. (2000), Resuscitation by Ferrioxamine E of Stressed Salmonella enterica Serovar Typhimurium from Soil and Water Microcosms; Appl. Environ. Microbiol. 66 4128
  4. Wilson et al. (2016), Siderophores in Iron Metabolism: From Mechanism to Therapy Potential; Trends Mol. Med. 22 1077
20008-20-2, Ferrioxamine, Ferrioxamine E, Ferrioxamine E supplier, hydroxamate siderophore
CAS:
20008-20-2
Catalog Number:
10-5156
Activity:
Siderophore
Chemical Names:
1,12,23-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone Iron(III) complex
Molecular Weight:
653.54
Molecular Formula:

C27H45FeN6O9

Solubility:
Soluble in DMSO (10 mg/ml); Water (0.75mg/mL)
Physical Properties:
Orange solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Ferrioxamine E (20008-20-2) is a hydroxamate siderophore. Siderophores like Ferrioxamine E make iron easier to access and absorb by cells. Their ability to chelate iron makes them useful in research on iron overload disorders such as hemochromatosis and sickle cell disease.1 Ferrioxamine E is used to enhance growth of certain bacterial species including Salmonella, Enterobacter saka-zakii and Yersinia enterocolitica.2 It does not improve growth of Escherichia coli, Shigella, Proteus, Providencia and Morganella species.3 Because siderophores are produced by bacteria as virulence factors, they are useful tools in infectious disease research.4

References/Citations:

  1. Nagoba and Vedpathak (2011), Medical Applications of Siderophores; Eur. J. Gen. Med. 8 229
  2. Pless and Reissbrodt (1995), Improvement of Salmonella detection on motility enrichment media by ferrioxamine E-supplementation of pre-enrichment culture; Int. J. Food Microbiol. 27 147
  3. Reissbrodt et al. (2000), Resuscitation by Ferrioxamine E of Stressed Salmonella enterica Serovar Typhimurium from Soil and Water Microcosms; Appl. Environ. Microbiol. 66 4128
  4. Wilson et al. (2016), Siderophores in Iron Metabolism: From Mechanism to Therapy Potential; Trends Mol. Med. 22 1077

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