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Fluvastatin Na | HMG CoA reductase inhibitor

Fluvastatin Na (CAS 93957-55-2) is a potent inhibitor of HMG-CoA reductase, IC50=40-100 nM.1  Clinically useful, orally active antihypercholesterolemic agent. Inhibits vascular smooth muscle proliferation, IC50=70 nM.2 Displays antineuroinflammatory activity.3 Prevents lung adenocarcinoma bone metastasis by triggering autophagy.4 Attenuates cell proliferation in hepatocellular carcinoma.5


1) Dansette et al. (2000), HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins; Exp. Toxicol. Pathol., 52 145
2) Turner et al. (2007), Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion: J. Cardiovasc. Pharmacol., 50 458
3) McFarland et al. (2017), Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-like Cells; Mediators Inflamm., Epub May 4
4) Yang et al. (2017), Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy; EBioMedicine, 19 49
5)Higashi et al. (2016), Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma; Med. Oncol., 33 123

Focus Biomolecules cell signaling supplier, chemical structure Fluvastatin Na | HMG CoA reductase inhibitor | CAS 93957-55-2

Catalog#  10-2554-0020

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Catalog Number:
HMG CoA reductase inhibitor
Chemical Name:
(+/-)(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Molecular Weight:
Molecular Formula:
C24H25FNO4 . Na
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 10 mg/ml)
Physical Properties:
Tan solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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