Golgicide A | GBF1 inhibitor

CAS:
 1005036-73-6
Catalog Number:
 10-3271
Golgicide A chemical structure

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Golgicide A (1005036-73-6) is a potent, specific, reversible inhibitor (IC50 = 3.3 mM) of Golgi-specific brefeldin A resistance factor 1 (GBF1) which is a guanine nucleotide exchange factor that targets ADP-ribosylation factor 1 (ARF1).1 Treatment of cells with golgicide A causes the rapid stripping of COPI protein coats from Golgi membranes and leads to the breakdown of the Golgi apparatus and the trans-Golgi network (TGN). Unlike BFA, golgicide does not inhibit other ARF-GEFs such as the BFA-inhibited guanine nucleotide-exchange protein-1 and -2 (BIG1 and BIG2). Golgicide A is a highly useful tool for studying anterograde and retrograde traffic through the Golgi and TGN.2-4

References/Citations:

  1. Saenz et al. (2009), Golgicide A reveals essential roles for GBF1 in Golgi assembly and function; Nat. Chem. Biol., 5 157
  2. He et al. (2025), Clathrin-Independent Carriers/Glycosylphosphatidylinositol-Anchored-Protein-Enriched Endosomal Compartment Endocytic Pathway Is Critical for Enterovirus A71 Entry Into Human Oral Epidermoid Carcinoma KB Cells; J. Med. Virol., 97 e70369
  3. Dogrammatzis et al. (2024), Tracing the STING exocytosis pathway during herpes viruses infection; mBio, 15 e00373-24
  4. Klabunde et al. (2023), Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner; Cell Commun. Signal., 21 208
1005036-73-6, CID 25113626, GBF1 inhibitor, GCA supplier, Golgicide, Golgicide A, Golgicide A supplier
CAS:
1005036-73-6
Catalog Number:
10-3271
Activity:
GBF1 inhibitor
Chemical Names:
6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolone (racemic)
Alternate Name:
GCA; CID 25113626
Molecular Weight:
284.31
Molecular Formula:

C17H14F2N2

Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Golgicide A (1005036-73-6) is a potent, specific, reversible inhibitor (IC50 = 3.3 mM) of Golgi-specific brefeldin A resistance factor 1 (GBF1) which is a guanine nucleotide exchange factor that targets ADP-ribosylation factor 1 (ARF1).1 Treatment of cells with golgicide A causes the rapid stripping of COPI protein coats from Golgi membranes and leads to the breakdown of the Golgi apparatus and the trans-Golgi network (TGN). Unlike BFA, golgicide does not inhibit other ARF-GEFs such as the BFA-inhibited guanine nucleotide-exchange protein-1 and -2 (BIG1 and BIG2). Golgicide A is a highly useful tool for studying anterograde and retrograde traffic through the Golgi and TGN.2-4

References/Citations:

  1. Saenz et al. (2009), Golgicide A reveals essential roles for GBF1 in Golgi assembly and function; Nat. Chem. Biol., 5 157
  2. He et al. (2025), Clathrin-Independent Carriers/Glycosylphosphatidylinositol-Anchored-Protein-Enriched Endosomal Compartment Endocytic Pathway Is Critical for Enterovirus A71 Entry Into Human Oral Epidermoid Carcinoma KB Cells; J. Med. Virol., 97 e70369
  3. Dogrammatzis et al. (2024), Tracing the STING exocytosis pathway during herpes viruses infection; mBio, 15 e00373-24
  4. Klabunde et al. (2023), Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H2O2-dependent manner; Cell Commun. Signal., 21 208

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