GPR35 and Neutrophil function

In a paper just out in Cell, Marco De Giovanni et al. at UCSF demonstrated that 5-hydroxyindoleacetic acid (5-HIAA), a platelet serotonin metabolite, acts as a physiological agonist at the orphan receptor GPR35 (G protein-coupled receptor 35). Activated GPR35 promotes neutrophil migration and recruitment to sites of inflammation and bacterial clearance. The study sheds light on the role of GPR35 in physiology and disease.

Orphan GPCR products

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