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Product Details

Indoximod | IDO modulator / tryptophan mimetic

Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4

References/Citations
1) Hou et al. (2007), Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses; Cancer Res., 67 792
2) Soliman et al. (2010), Indoleamine 2,3-dioxygenase: is it an immune suppressor?; Cancer J., 16 354
3) Friberg et al. (2002), Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T-cell mediated rejection; Int. J. Cancer, 101 151
4) Metz et al. (2012), IDO inhibits a tryptophan sufficiency signal that stimulates mTOR; Oncoimmunol., 1 1460

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Catalog#  10-4569

$20.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
110117-83-4
Catalog Number:
10-4569
Activity:
IDO modulator / tryptophan mimetic
Chemical Name:
1-Methyl-D-tryptophan
Molecular Weight:
218.25
Molecular Formula:
C12H14N2O2
Solubility:
Soluble in DMSO (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
>98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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