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Indoximod | IDO modulator / tryptophan mimetic

Indoximod (110117-83-4) is a modulator of indoleamine 2,3-dioxygenase (IDO) activity.1 IDO can be used by tumors to avoid elimination by the host immune response2,3, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects.3 IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.4

1) Hou et al. (2007), Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses; Cancer Res., 67 792
2) Soliman et al. (2010), Indoleamine 2,3-dioxygenase: is it an immune suppressor?; Cancer J., 16 354
3) Friberg et al. (2002), Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T-cell mediated rejection; Int. J. Cancer, 101 151
4) Metz et al. (2012), IDO inhibits a tryptophan sufficiency signal that stimulates mTOR; Oncoimmunol., 1 1460

Focus Biomolecules reagent supplier, chemical structure of Indoximod | IDO modulator / tryptophan mimetic | CAS 110117-83-4

Catalog#  10-4569

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Catalog Number:
IDO modulator / tryptophan mimetic
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (greater than 25 mg/ml).
Physical Properties:
White solid
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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