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Isofagomine tartrate | Glucocerebrosidase activator and chaperone

Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50 = 0.06 μM.1 Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2 Displays a direct pharmacological chaperone effect greatly increasing the amount of newly synthesized GlcCerase that traffics out of the ER.2

References/Citations

1) Kuriyama et al. (2008), In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culture; Bioorg. Med. Chem., 16 7330
2) Steet et al. (2006), The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms; Proc. Natl. Acad. Sci. USA, 103 13813

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Focus Biomolecules, chemical structure Isofagomine tartrate | Glucocerebrosidase activator, chaperone | CAS 957230-65-8

Catalog#  10-2859-0001

$100.00
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CAS:
957230-65-8
Catalog Number:
10-2859
Activity:
Glucocerebrosidase activator and chaperone
Chemical Name:
(3R,4R,5R)-5-Hydroxymethyl-3,5-piperidinediol tratrate
Molecular Weight:
297.26
Molecular Formula:
C6H13NO3 &bul; C4H6O6
Solubility:
Soluble in DMSO (up to 2 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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