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Product Details

Kifunensine | Mannosidase inhibitor

Historically isolated from Kitasatosporia kifunense.1 Kifunensine (CAS 109944-15-2) is an inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum a-mannosidase I activity rescues the human a-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair a-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4


1) Iwami et al. (1987), A new immunomodulator, FR-900494: taxonomy, fermentation, isolation, and physico-chemical and biological characteristics; J.Antibiot. (Tokyo) 40 612
2) Elbein et al. (1990), Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I;  J.Biol.Chem. 265 15599
3) Bartoli et al. (2008), Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation;  Hum.Mol.Genet. 17 1214
4) Wang et al. (2011), Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases; J.Biol.Chem. 286 43454

Focus Biomolecules cell signaling reagent supplier, chemical structure Kifunensine | Mannosidase inhibitor | CAS 109944-15-2

Catalog#  10-2860-0001

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Catalog Number:
Mannosidase inhibitor
Chemical Name:
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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