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Kynurenine (L) | Endogenous AhR agonist

Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2

References/Citations
1) Ibana et al. (2011), Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun., 79 4425
2) Opitz et al. (2011), An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature, 478 197

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Focus Biomolecules supplier, chemical structure of Kynurenine (L) | Endogenous AhR agonist | CAS 2922-83-0

Catalog#  10-2666

$38.00
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CAS:
2922-83-0
Catalog Number:
10-2666
Activity:
Endogenous AhR agonist
Chemical Name:
β-Anthraniloyl-L-alanine; L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Molecular Weight:
208.22
Molecular Formula:
C10H12N2O3
Solubility:
Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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