Lactoyl phenylalanine | Anorexigenic circulating metabolite

CAS:
 183241-73-8
Catalog Number:
 10-5713
Lactoyl phenylalanine chemical structure

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Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-regulatory hormone such as GLP-11 or the increase in circulating metabolites including L-lactate2. A targeted metabolomics approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine (Lac-Phe; 183241-73-8) as a highly upregulated circulating metabolite following exercise.3 Lac-Phe was shown, using pharmacological and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.4

References/Citations:

  1. Hazell et al. (2016), Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms; Appetite, 98 80
  2. McCarthy et al. (2020), The emerging role of lactate as a mediator of exercise-induced appetite suppression; J. Endocrinol. Metab., 319 E814
  3. Lund et al. (2022), Outrunning obesity with Lac-Phe?; Cell Metab., 34 P1085
  4. Li et al. (2022), An exercise-inducible metabolite that suppresses feeding and obesity; Nature, 606 785
183241-73-8, Lac-Phe, Lac-Phe supplier, Lactoyl phenylalanine, Lactoyl phenylalanine supplier
CAS:
183241-73-8
Catalog Number:
10-5713
Activity:
Anorexigenic circulating metabolite
Chemical Names:
N-[(2S)-2-hydroxy-1-oxopropyl]-L-phenylalanine
Alternate Name:
Lac-Phe
Molecular Weight:
237.26
Molecular Formula:

C12H15NO4

Solubility:
Soluble in DMSO (>50 mg/ml with warming)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

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Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-regulatory hormone such as GLP-11 or the increase in circulating metabolites including L-lactate2. A targeted metabolomics approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine (Lac-Phe; 183241-73-8) as a highly upregulated circulating metabolite following exercise.3 Lac-Phe was shown, using pharmacological and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.4

References/Citations:

  1. Hazell et al. (2016), Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms; Appetite, 98 80
  2. McCarthy et al. (2020), The emerging role of lactate as a mediator of exercise-induced appetite suppression; J. Endocrinol. Metab., 319 E814
  3. Lund et al. (2022), Outrunning obesity with Lac-Phe?; Cell Metab., 34 P1085
  4. Li et al. (2022), An exercise-inducible metabolite that suppresses feeding and obesity; Nature, 606 785