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LM22A-4 | TrkB small molecule agonist

LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1 Improves respiratory function in a mouse models of Rett syndrome.2

1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774
2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803

Focus Biomolecules supplier, chemical structure of LM22A-4 | TrkB small molecule agonist | CAS 37988-18-4

Catalog#  10-1405

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Catalog Number:
TrkB small molecule agonist
Chemical Name:
N,N',N' Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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