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Product Details

Lomerizine | Calcium Channel Blocker

Lomerizine (101477-54-7)is a clinically useful calcium channel blocker (L and T-type).  It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A antagonistic effects.1 Lomerizine also displays anti-glaucoma effects via an increase in ocular circulation and protection of neuronal cells against retinal neurotoxicity with minimal cardiovascular effects.2 Lomerizine has also shown various other neuroprotective properties.3,4,5,6

References/Citations

1) Ishii et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery;  J.Pharmacol.Sci. 111 221
2) Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199
3) Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol.Cell Biochem. 358 1
4) Savigni et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma;  Neuropharmacology 75 380
5) Tran et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43;  J.Neurochem. 130 455
6) O'Hare et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro;  Neuroscience 339 450

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Catalog#  10-4336-0010

$40.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
101477-54-7
Catalog Number:
10-4336
Activity:
Calcium Channel Blocker
Chemical Name:
1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
Alternate Names:
KB-2796
Molecular Weight:
541.46
Molecular Formula:
C27H30F2N2O3•2HCl
Solubility:
Soluble in DMSO (up to 45 mg/ml) and Ethanol (30 mg/ml)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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