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Product Details

Lomerizine | Calcium Channel Blocker

Lomerizine (101477-54-7)is a clinically useful calcium channel blocker (L and T-type).  It is used for the treatment of migraine headaches, however its antimigraine effects are believed to be due to its 5HT2A antagonistic effects.1 Lomerizine also displays anti-glaucoma effects via an increase in ocular circulation and protection of neuronal cells against retinal neurotoxicity with minimal cardiovascular effects.2 Lomerizine has also shown various other neuroprotective properties.3,4,5,6


1) Ishii et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery;  J.Pharmacol.Sci. 111 221
2) Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199
3) Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol.Cell Biochem. 358 1
4) Savigni et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma;  Neuropharmacology 75 380
5) Tran et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43;  J.Neurochem. 130 455
6) O'Hare et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro;  Neuroscience 339 450

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Catalog#  10-4336-0010

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Catalog Number:
Calcium Channel Blocker
Chemical Name:
1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 45 mg/ml) and Ethanol (30 mg/ml)
Physical Properties:
White solid
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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