Methotrexate | Dihydrofolate reductase inhibitor
CAS:
133073-73-1
Catalog Number:
10-1260
Activity:
Dihydrofolate reductase inhibitor
Chemical Names:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740
Molecular Weight:
683.63
Molecular Formula:
C20H22N8O5·XH2O
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 100 mg | $50.00 | ||
| 500 mg | $150.00 |
Methotrexate (133073-73-1) is a synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity.1 Inhibits thymidylate synthetase and de novo purine synthesis.2,3 Displays beneficial effects in rheumatoid arthritis by inhibiting the production of cytokines induced by T-cell activation4 and stimulation of adenosine release5. It is the classic disease-modifying antirheumatic drug (DMARD).6
References:
- Wessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249
- Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520
- Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470
- Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189
- Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301
- Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473
CAS:
133073-73-1
Catalog Number:
10-1260
Activity:
Dihydrofolate reductase inhibitor
Chemical Names:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740
Molecular Weight:
683.63
Molecular Formula:
C20H22N8O5·XH2O
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Methotrexate (133073-73-1) is a synthetic folic acid analog with immunosuppressant and cancer chemotherapeutic activity.1 Inhibits thymidylate synthetase and de novo purine synthesis.2,3 Displays beneficial effects in rheumatoid arthritis by inhibiting the production of cytokines induced by T-cell activation4 and stimulation of adenosine release5. It is the classic disease-modifying antirheumatic drug (DMARD).6
References:
- Wessels et al. (2008), Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis; Rheumatology (Oxford), 47 249
- Allegra et al. (1987), Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate; Biol. Chem., 262 13520
- Chu et al. (1990), Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells; Biol. Chem., 265 8470
- Gerards et al. (2003), Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis; Rheumatology (Oxford), 42 1189
- Friedman and Cronstein (2019), Methotrexate mechanism in treatment of rheumatoid arthritis; Joint Bone Spine, 86 301
- Smolen and Steiner (2003), Therapeutic strategies for rheumatoid arthritis; Rev. Drug Discov., 2 473
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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