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MG-132 | Proteasome inhibitor

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

References/Citations

) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,  119 572
2) Wu  et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228
3) Meriin  et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373
4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

 

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Focus Biomolecules cell signaling reagent supplier, chemical structure MG-132 | Proteasome inhibitor | CAS 133407-82-6

Catalog#  10-1309

$50.00
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CAS:
133407-82-6
Catalog Number:
10-1309
Activity:
Proteasome inhibitor
Alternate Names:
Z-Leu-Leu-Leu-CHO
Chemical Name:
N-(Benzyloxycarbonyl)leucinylleucinylleucinal
Molecular Weight:
475.63
Molecular Formula:
C26H41N3O5
Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 45 mg/ml), or in Ethanol (up to 45 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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