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Product Details

ML-SA1 | TRPML activator

ML-SA1 (332382-54-4) is a TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4


1) Grimm et al. (2010), Small molecule activators of TRPML3; Mol. Chem. Biol., 17 135
2) Shen et al. (2012), Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun., 3 731
3) Weiss et al. (2012), Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol., 5 111
4) Zou et al. (2015), Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells; J. Neurosci.. 35 6801

Focus Biomolecules cell signaling reagent supplier, chemical structure of ML-SA1 | TRPML activator | CAS 332382-54-4

Catalog#  10-1439

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Catalog Number:
TRPML activator
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Tan solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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