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Monastrol | Kinesin Eg5 and mitosis inhibitor

CAS:
254753-54-3
Catalog Number:
10-2629
Activity:
Kinesin Eg5 and mitosis inhibitor
Chemical Name:
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Molecular Weight:
292.35
Molecular Formula:
C14H16N2O3S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM).2 Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory.3 Enhances regeneration of adult axons.4

References/Citations:

1) Mayer et al. (1999), Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen; Science, 286 971
2) Kapoor et al. (2000), Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of mitotic kinesin, Eg5; J. Cell Biol., 150 975
3) Ari et al. (2014), Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function; Neurobiol. Aging, 35 1839
4) Lin et al. (2011), Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons; Traffic, 12 269

Monastrol | Kinesin Eg5 and mitosis inhibitor is also available in the Cellular Metabolism Library.
CAS:
254753-54-3
Catalog Number:
10-2629
Activity:
Kinesin Eg5 and mitosis inhibitor
Chemical Name:
1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Molecular Weight:
292.35
Molecular Formula:
C14H16N2O3S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

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