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Product Details

NA-Gly | GPR18 agonist

NA-Gly (179113-91-8) is an endogenous anti-inflammatory lipo-amino acid1. Full agonist at GPR182,3. Induces macrophage apoptosis via GPR184 which may be a mechanism for its resolution of inflammation activity5.

1) Huang et al. (2001), Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain; J. Biol. Chem., 276 42639
2) McHugh et al. (2012), Δ(9)-Tetrahydrocannabinol and N-arachidonylglycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells; Br. J. Pharmacol., 165 2414
3) McHugh et al. (2012), siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonyl glycine-induced cell migration; J. Mol. Signal., 7 10
4) Takenouchi et al. (2012), N-arachidonyl glycine induces macrophage apoptosis via GPR18; Biochem. Biophys. Res. Commun., 418 366
5) Burstein et al. (2011), Resolution of inflammation by N-arachidonoylglycine; J. Cell Biochem., 112 3227
6) [FOCUS CITATION] Console-Bram et al. (2017), N-arachidonoyl glycine, another endogenous agoinst of GPR55; Biochem. Biiophys. Res. Commun., 490 1389

Focus Biomolecules cell signaling reagent supplier, chemical structure of NA-Gly | GPR18 agonist | CAS 179113-91-8

Catalog#  10-1200

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Catalog Number:
GPR18 agonist
Alternate Names:
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Beige waxy solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
Blue Ice
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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