In Nature Communications, Zhang et al. show that DJ001, a selective allosteric inhibitor of protein tyrosine phosphatase sigma (PTPσ), promotes hematopoietic stem cell (HSC) regeneration. Treatment
In a fascinating paper just out in Cell Metabolism, Mathias Wenes and coworkers found that the mitochondrial pyruvate carrier (MPC) regulates memory T cell differentiation and
CHIR-99021 is another popular tool for stem cell maintenance which increases cell survival and proliferation. It is a GSK3β inhibitor, and Komiya et al. used CHIR-99021
The compound Y-27632 inhibits ROCK family kinases and is a very popular tool for embryonic stem cell (ESC) maintenance because it enhances survival and proliferation in
Ferroptosis is a type of cell death caused by iron-dependent peroxidation of phospholipids and is important for proper function of tumor suppression, immune surveillance, and the
Disrupting N-glycan expression on tumor cells enhanced CAR T cell efficacy. Greco et al. treated mice with 2-deoxy-D-glucose (Focus Cat.# 10-2171), a glucose analog, disrupting N-glycan
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