In a paper just out in Cell, Marco De Giovanni et al. at UCSF demonstrated that 5-hydroxyindoleacetic acid (5-HIAA), a platelet serotonin metabolite, acts as a
NSD2 (nuclear receptor-binding SET domain-containing 2) is a methyltransferase that specifically targets histone H3 at Lysine 36 (making it a H3K36me2 in chromatin remodeling nomenclature). It
In a PNAS paper just out Yu and coworkers showed that the small molecule NEDD8-activating enzyme (NAE) inhibitor MLN4924 (pevonedistat, Focus Cat# 10-1311) reduces ischemic brain
A team at Toronto’s Hospital for Sick Children demonstrated that pharmacological ablation of senescent cells using Navitoclax (ABT-263, Focus Cat#10-3141) caused a rapid increase in neural
The 2021 Nobel Prize in Medicine was awarded to David Julius and Ardem Patapoutian because of their research on TRPV1 (Transient Receptor Potential Vanilloid 1) and
The emergence of SARS-CoV-2 has precipitated an unprecedented effort by the scientific community to find and develop potential therapeutics and vaccines for this new virus to
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