In a paper just out in Cell, Marco De Giovanni et al. at UCSF demonstrated that 5-hydroxyindoleacetic acid (5-HIAA), a platelet serotonin metabolite, acts as a physiological agonist at the orphan receptor GPR35 (G protein-coupled receptor 35). Activated GPR35 promotes neutrophil migration and recruitment to sites of inflammation and bacterial clearance. The study sheds light on the role of GPR35 in physiology and disease.
