J Zhang and coworkers at Leiden University Med Ctr have shown that a splice variant of the ubiquitin specific protease, USP19-CY, can enhance the epithelial-mesenchymal transition
In a paper just out in Phytomedicine, HG Kim and coworkers describe the in vitro anti-cancer activity of Beauvericin, an antimicrobial metabolite from the fungus Beauveria
Resorcylic acid lactones are a diverse family of fungal natural products which possess a variety of useful pharmacological activities. For example: Radicicol Hypothemycin and others are
Apoptolidin is a novel microbial natural product isolated from Nocardiopsis sp. It was shown to be a powerful inducer of apoptosis in a variety of cancer
In a recent paper in Nature, Bryan Roth et al. revealed detailed features in the recognition of DREADD actuators by designer receptors. Muscarinic DREADDs or designer
Urolithin A is a microbial metabolite of dietary ellagitannins produced in the gut. It has been shown to induce mitophagy and prolong lifespan in C. elegans
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