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Product Details

NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling

NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling1. NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 μM, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity2. NOTUM inhibitors have potential as new therapeutics for degenerative diseaes3.

References/Citations
1) Zhang et al. (2016), Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes Tiki and Notum; Methods Mol. Biol., 1481 29
2) Atkinson et al. (2019), Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen; Med. Chem. Commun., Advance Article
3) Suciu et al. (2018), Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling; ACS Med. Chem. Lett., 9 563

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Catalog#  10-3756-0005

$55.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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Catalog Number:
10-3756
Activity:
NOTUM inhibitor, restores Wnt signaling
Chemical Name:
N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamide
Molecular Weight:
292.33
Molecular Formula:
C18H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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