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P7C3 | Neuroprotective agent

P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo.

1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39
2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016
3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010
4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86
5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324

Focus Biomolecules cell signaling reagent supplier, chemical structure of P7C3 | Neuroprotective agent | CAS 301353-96-8

Catalog#  10-1150

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Catalog Number:
Neuroprotective agent
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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