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P7C3 | Neuroprotective agent

P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo.

References/Citations
1) Pieper et al. (2010), Discovery of a proneurogenic, neuroprotective chemical; Cell, 142 39
2) Tesla et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis; Proc. Natl. Acad. Sci. USA, 109 17016
3) De Jesus-Cortes et al. (2012), Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease; Proc. Natl. Acad. Sci. USA, 109 17010
4) Latchney et al. (2015), Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome; Neurosci. Lett. 591 86
5) Wang et al. (2014), P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage; Cell, 158 1324

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Focus Biomolecules cell signaling reagent supplier, chemical structure of P7C3 | Neuroprotective agent | CAS 301353-96-8

Catalog#  10-1150

$60.00
Quantity
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CAS:
301353-96-8
Catalog Number:
10-1150
Activity:
Neuroprotective agent
Chemical Name:
1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
Molecular Weight:
474.2
Molecular Formula:
C21H18Br2N2O
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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