Phosphoramidon | Neutral endopeptidase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $100.00 | ||
| 25 mg | $400.00 |
Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1 Also inhibits neprilysin 2 (Ki~2 nM).2 Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM).3 Induces a dramatic increase in amyloid-beta levels in rodents.4
References/Citations:
1) Stephenson and Kenny et al. (1987), The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J., 243 183.
2) Rose et al. (2002), Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J., 363 697
3) Ahn et al. (1998), Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys., 359 258
4) Marr and Hafez (2014), Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci., 6 187
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1 Also inhibits neprilysin 2 (Ki~2 nM).2 Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM).3 Induces a dramatic increase in amyloid-beta levels in rodents.4
References/Citations:
1) Stephenson and Kenny et al. (1987), The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J., 243 183.
2) Rose et al. (2002), Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J., 363 697
3) Ahn et al. (1998), Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys., 359 258
4) Marr and Hafez (2014), Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci., 6 187
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1-855-FOCUS21
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