Intelliscreen™ Polycomb Repressive Complex Inhibitors Mini-Library

The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response. The Intelliscreen™ Polycomb Repressive Complex mini-library contains inhibitors of PCR1 members BMI1, CBX, and RING1, PCR2 members EZH2 and EED, as well as the polycomb-group deubiquitinase BAP1.

Catalog Number:
10-7315
Description:
7 inhibitors of the polycomb-group proteins.
Solubility:
DMSO
Supplied As:
DMSO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$395.00

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

The PRC mini-library includes the following components for studying the important areas of this pathway.

  • DZNep HCl | Methyltransferase inhibitor

    CAS:
    120964-45-6
    Catalog Number:
    10-1524
    Activity:
    Methyl transferase inhibitor
    Chemical Name:
    (1S,2R,5R)-5-(4-Aminoimidazo[4,5-c]pyridine-1-yl)-3-(hydroxymethyl)-cyclopent-3-ene-1,2-diol hydrochloride
    Alternate Names:
    3-Deazaneplanocin A HCl; NSC 617989
    Molecular Weight:
    298.73
    Molecular Formula:
    C12H14N4O3 ·HCl
    Solubility:
    Soluble in Water (up to 40 mg/ml)
    Physical Properties:
    Beige solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
    From $142.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • EED-226 | PRC2 methyltransferase inhibitor

    CAS:
    2083627-02-3
    Catalog Number:
    10-4021
    Activity:
    PRC2 methyltransferase inhibitor
    Chemical Name:
    N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine
    Molecular Weight:
    369.40
    Molecular Formula:
    C17H15N5O3S
    Solubility:
    Soluble in DMSO (up to 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $85.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • iBAP-II | BAP1 inhibitor

    CAS:
    1013813-81-4
    Catalog Number:
    10-4038
    Activity:
    BAP1 inhibitor
    Chemical Names:
    4-(8-Nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-yl)phenol
    Molecular Weight:
    308.33
    Molecular Formula:
    C18H16N2O3
    Solubility:
    Soluble in DMSO (25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $85.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • PRT4165 | Bmi1/Ring1A inhibitor

    CAS:
    31083-55-3
    Catalog Number:
    10-1478
    Activity:
    Bmi1/Ring1A inhibitor
    Chemical Name:
    2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
    Molecular Weight:
    235.24
    Molecular Formula:
    C15H9NO2
    Solubility:
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming).
    Physical Properties:
    Yellow solid
    Purity:
    98% by TLC
    NMR (Conforms)
    Storage Temperature:
    RT
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $65.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • PTC-209 | BMI-1 inhibitor

    CAS:
    315704-66-6
    Catalog Number:
    10-4022
    Activity:
    BMI-1 inhibitor
    Chemical Names:
    N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine
    Molecular Weight:
    495.19
    Molecular Formula:
    C17H13Br2N5OS
    Solubility:
    Soluble in DMSO (>25 mg/ml)
    Physical Properties:
    Yellow solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
    From $60.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • Tazemetostat | EZH2 inhibitor

    CAS:
    1403254-99-8
    Catalog Number:
    10-4032
    Activity:
    EZH2 inhibitor
    Chemical Name:
    N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1’-biphenyl]-3-carboxamide
    Alternate Name:
    EPZ-6438
    Molecular Weight:
    572.75
    Molecular Formula:
    C34H44N4O4
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    Off-white solid
    Purity:
    98%
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
    Shipping Code:
    RT
    From $55.00
    View Product This product has multiple variants. The options may be chosen on the product page
  • UNC3866 | Chromodomain inhibitor

    CAS:
    1872382-47-2
    Catalog Number:
    10-4025
    Molecular Weight:
    795.02

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