Intelliscreen™ Polycomb Repressive Complex Inhibitors Mini-Library
The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response. The Intelliscreen™ Polycomb Repressive Complex mini-library contains inhibitors of PCR1 members BMI1, CBX, and RING1, PCR2 members EZH2 and EED, as well as the polycomb-group deubiquitinase BAP1.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
The PRC mini-library includes the following components for studying the important areas of this pathway.
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DZNep HCl | Methyltransferase inhibitor
From $142.00CAS:120964-45-6Catalog Number:10-1524Activity:Methyl transferase inhibitorChemical Name:(1S,2R,5R)-5-(4-Aminoimidazo[4,5-c]pyridine-1-yl)-3-(hydroxymethyl)-cyclopent-3-ene-1,2-diol hydrochlorideAlternate Names:3-Deazaneplanocin A HCl; NSC 617989Molecular Weight:298.73Molecular Formula:C12H14N4O3 ·HClSolubility:Soluble in Water (up to 40 mg/ml)Physical Properties:Beige solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.Shipping Code:RT -
EED-226 | PRC2 methyltransferase inhibitor
From $85.00CAS:2083627-02-3Catalog Number:10-4021Activity:PRC2 methyltransferase inhibitorChemical Name:N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amineMolecular Weight:369.40Molecular Formula:C17H15N5O3SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
iBAP-II | BAP1 inhibitor
From $85.00CAS:1013813-81-4Catalog Number:10-4038Activity:BAP1 inhibitorChemical Names:4-(8-Nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-yl)phenolMolecular Weight:308.33Molecular Formula:C18H16N2O3Solubility:Soluble in DMSO (25 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
PRT4165 | E3 ubiquitin ligase inhibitor
From $65.00CAS:31083-55-3Catalog Number:10-1478Activity:E3 ubiquitin ligase inhibitorChemical Name:2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dioneMolecular Weight:235.24Molecular Formula:C15H9NO2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
PTC-209 | BMI-1 inhibitor
From $60.00CAS:315704-66-6Catalog Number:10-4022Activity:BMI-1 inhibitorChemical Names:N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamineMolecular Weight:495.19Molecular Formula:C17H13Br2N5OSSolubility:Soluble in DMSO (>25 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Tazemetostat | EZH2 inhibitor
From $55.00CAS:1403254-99-8Catalog Number:10-4032Activity:EZH2 inhibitorChemical Name:N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1’-biphenyl]-3-carboxamideAlternate Name:EPZ-6438Molecular Weight:572.75Molecular Formula:C34H44N4O4Solubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Off-white solidPurity:98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
UNC3866 | Chromodomain inhibitor
CAS:1872382-47-2Catalog Number:10-4025Molecular Weight:795.02
