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Prostratin | Promotes neuro-regeneration

Prostratin (60857-08-1) is a terpenoid, non-tumorigenic PKC activator isolated from Pimelia prostrata.1,2 Induces differentiation of human myeloid leukemia cells and potentiates differentiation by chemotherapeutic agents.3 Induces reactivation of latent HIV.4 Exerts a proliferative effect on neural progenitor cells in vitro and in vivo.5


1) Cashmore et al. (1976), The structure of prostratin: a toxic tetracyclic diterpene ester from Pimelea Prostrata; Tetrahedron Lett., 17 1737
2) Miana et al. (2015), Prostratin: An Overview; Mini Rev. Med. Chem., 15 1122
3) Shen et al. (2015), The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents; Cancer Lett., 356 (2 Pt. B) 686
4) Biancotto et al. (2004), Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue; J. Virol., 78 10507
5) Geribaldi-Doldan et al. (2015), 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC activation ; Int. J, Neuropsychopharmacol., 19 pyv085

Focus Biomolecules cell signaling supplier, chemical structure of Prostratin | Promotes neuro-regeneration | CAS 60857-08-1

Catalog#  10-2169-0001

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Catalog Number:
Promotes neuro-regeneration
Chemical Name:
Alternate Names:
12-Deoxyphorbol 13-Acetate; dPAc
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Off-white solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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