PZL-A | mtDNA activator

CAS:
 3068830-89-4
Catalog Number:
 10-4421

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PZL-A (3068830-89-4) is a first-in-class activator of mammalian mitochondrial DNA (mtDNA). AC50’s: 160 nM for A467T mutant; 20 nM for G848S mutant.  mtDNA, which encodes essential protein subunits of the oxidative phosphorylation complexes, is replicated by the DNA polymerase POLγ. PZL-A restores function to mutant POLγ via binding to an allosteric site between the catalytic subunits POLγA and POLγB. An important new tool for studying mitochondrial disorders.

References/Citations:

  1. Valenzuela et al. (2025), Small molecules restore mutant mitochondrial DNA polymerase activity; Nature, 642 501
3068830-89-4, mtDNA activator, PZL-A, PZL-A supplier, PZLA
CAS:
3068830-89-4
Catalog Number:
10-4421
Activity:
mtDNA activator
Chemical Names:
1-[(4S)-8-Chloro-3,4-dihydro-2H-chromen-4-yl]-3-(1-phenylpyrazol-3-yl)urea
Alternate Name:
(S)-1-(8-chlorochroman-4-yl)-3-(1-phenyl-1H-pyrazol-3-yl)urea
Molecular Weight:
368.82
Molecular Formula:

C19H17ClN4O2

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale yellow solid
Purity:

>97% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

PZL-A (3068830-89-4) is a first-in-class activator of mammalian mitochondrial DNA (mtDNA). AC50’s: 160 nM for A467T mutant; 20 nM for G848S mutant.  mtDNA, which encodes essential protein subunits of the oxidative phosphorylation complexes, is replicated by the DNA polymerase POLγ. PZL-A restores function to mutant POLγ via binding to an allosteric site between the catalytic subunits POLγA and POLγB. An important new tool for studying mitochondrial disorders.

References/Citations:

  1. Valenzuela et al. (2025), Small molecules restore mutant mitochondrial DNA polymerase activity; Nature, 642 501

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