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Product Details

(R)-PFI-2 HCl | Methyltransferase SETD7 inhibitor

(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.

References/Citations

1) Barsyte-Lovejoy et al. (2014), (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells; Proc. Natl. Acad. Sci. USA 111 12853

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Catalog#  10-4033-0005

$99.00
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CAS:
1627607-87-7
Catalog Number:
10-4033
Activity:
Methyltransferase SETD7 inhibitor
Chemical Name:
(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
Molecular Weight:
535.98
Molecular Formula:
C23H25F4N3O3S HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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