(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.
1) Barsyte-Lovejoy et al. (2014), (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells; Proc. Natl. Acad. Sci. USA 111 12853