E3 Ubiquitin ligase
-
Adavosertib | Wee1 kinase inhibitor
From $45.00CAS:955365-80-7Catalog Number:10-4823Activity:Wee1 kinase inhibitorChemical Names:1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-oneAlternate Name:MK-1775; AZD1775Molecular Weight:500.61Molecular Formula:C27H32N8O2Solubility:Soluble in DMSO (70 mg/ml)Physical Properties:Yellow solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
CC-90009 | Cereblon modulator/Molecular glue
From $75.00CC-90009 (1860875-51-9) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex that specifically targets GSPT1 (G1 to S phase transition 1; EC50 […]
-
Heclin | HECT domain containing E3 ubiquitin ligase inhibitor
From $60.00CAS:890605-54-6Catalog Number:10-1534Activity:HECT domain containing E3 ubiquitin ligase inhibitorChemical Name:2E-N-(4-Acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamideMolecular Weight:283.33Molecular Formula:C17H17NO3Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. -
Iberdomide | Cereblon modulator/Molecular glue
From $75.00Iberdomide (1323403-33-3) is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide […]
-
Indisulam | RBM39 Molecular glue
From $65.00Indisulam (165668-41-7) was originally described as a potent antitumor agent that targeted the G1 phase of cell cycle via suppression of activation of CDK2 and cyclin […]
