p53 & Other Tumor Suppressors
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CBL0137 | Inhibitor of the histone chaperone FACT
From $80.00CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome […]
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NSC59984 | p53 activator
From $60.00CAS:803647-40-7Catalog Number:10-3148Activity:P53 activatorChemical Name:(E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-oneMolecular Weight:265.27Molecular Formula:C12H15N3O4Solubility:Soluble in DMSO (up to 20 mg/ml)Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
NSC66811 | p53/mdm2 inhibitor
From $100.00CAS:6964-62-1Catalog Number:10-1334Activity:p53/mdm2 inhibitorChemical Name:2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinolMolecular Weight:340.43Molecular Formula:C23H20N2OSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:97% by TLC/HPLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.Shipping Code:RT -
Nutlin-3 | p53/mdm2 inhibitor
From $100.00CAS:548472-68-0Catalog Number:10-1350Activity:p53/mdm2 inhibitorChemical Name:(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-oneMolecular Weight:581.51Molecular Formula:C30H30Cl2N4O4Solubility:Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
Phenylhexyl isothiocyanate | Chemopreventive; HDAC inhibitor; p53 reactivator
From $50.00Isothiocyanate constituents of cruciferous vegetables are potent chemopreventive agents for carcinogen-induced cancers in rodents.1 Phenylhexyl isothiocyanate (PHITC; CAS 133920-06-6) was the most potent in a series […]
EXPLORE OTHER Cancer
- ADC warheads
- Angiogenesis
- Autophagy
- Cancer Cell Metabolism
- Cancer Stem Cells
- Cell Cycle
- Cellular Stress
- Chemotherapeutics
- Cytoskeleton
- DNA Damage/Repair
- Drug resistance
- Epigenetics
- Gene Regulation/Transcription
- Growth factors
- Immuno-oncology
- Kinases
- Metastasis
- Other Cancer
- Programmed cell death
- Stem Cells
- Ubiquitin proteasome
